Did you know there are over 7,000 known rare diseases? Follow our narrator, Effie, as she uses the alphabet to explain 26 rare diseases in a scientifically accurate, but easy to understand, way.

Featured rare diseases include: Aicardi Syndrome, Baraitser Winter Syndrome, CDKL5 Deficiency Disorder, Desanto-Shinawi Syndrome, Ectodermal Dysplasia, FOXG1 Syndrome, Glycogen storage disease, Hemimegalencephaly, Infantile Bullous Pemphigoid, Joubert Syndrome, Kabuki Syndrome, Leukodystrophy/Leuden Syndrome, Moebius Syndrome, Non-ketotic hyperglycinemia, Osteogenesis Imperfecta, Prader Willi Syndrome, 22Q13- Phelan McDermid Syndrome, Russell Silver Syndrome, Sanfilippo Syndrome, Tuberous Sclerosis Complex, undiagnosed, Vein of Galen Malformation, Wolf Hirschhorn Syndrome, Xia-Gibbs Syndrome, PYROXD-1, and Zimmerman Laband syndrome.